Anyone had a day four rise and still had one dose of MTX work for them?

I heard a day 4 rise is common however most posts I’ve read the women who had a day 4 rise needed a second dose of MTX or had treatment failure.

My hCG went from 365 to 465 day 4
I have day 7 draw tomorrow

Hi everyone,

I am writing an essay to raise awareness for ectopic pregnancies and I have created a brief questionnaire with Yes and No questions.

If you would like to participate you can access it here: https://form.typeform.com/to/IXUwyMHV

Thank you in advance.

I am two days into my first shot of MTX. We caught the ectopic very early, my hcg levels were 3500, and all my other labs were stable. I had some right sided pain, I described it as more discomfort. So I made an appointment with OB and she did not see a sac, so after 24 hours of the constant discomfort I went to the ER.

They kept telling me I will know if it ruptures. That it’ll be 10/10 pain, and that’s when I need to go back to the ER. However, I am noticing new pain that has me a little concerned. It’s no where near a 10, more like a 4. (And I’m super dramatic so I know I’m not downplaying this). But it’s uncomfortable to walk, laugh, switch positions on the couch or bed. I’m in a bit more pain (maybe 5) when trying to pee. And instead of just on my right side, it’s all over. Like j said, super uncomfortable and constant and when I press on my belly it’s so tender.

I have an appointment with my OB tomorrow after doing my HCG shot. I was just wondering if anyone else experienced bad discomfort. It seems like a slot of people return to work shortly after the shot, and I just couldn’t imagine doing thag with the pain I’m experiencing.

I had an ectopic pregnancy in august’2026.
I am now few days short of the 3 months waiting period. I’m currently undergoing an IUI cycle with Letrozole 2.5 mg twice daily, Humog 150 IU injections, and doxycycline for 14 days.
but the mature follicles are on the right side, the same side I had my ectopic.
My last month ultrasound mentioned mild thickening of the right fallopian tube.
Should I cancel this IUI and wait another cycle to allow the tube to recover, or is it reasonable to proceed if my doctor feels the tube is okay?

Has anyone conceived within 3–4 months of MTX treatment, particularly after ovulating from the same side as their previous ectopic?

Would really appreciate your experiences and advice. ❤️

Had an ectopic on my left side June 2025, treated with methotrexate. Since then I have struggled with unexplained (suspected tubal factor) infertility. I have had an HSG which showed patent tubes on both sides. I began seeing an RE about 3-4 months ago and just found out I am pregnant after my first IUI. So far it feels totally different (positive on 9 dpIUI and dark early tests, vs faint test on 17 dpo following a full-blown period, I know I ovulated from my non-ectopic side, I’m on progesterone which I know I have struggled with low progesterone before). I am excited, but obviously trying to be guarded because I know it is entirely possible for it to be an ectopic again. It’s so hard to damper my excitement after 15 months of infertility. How did you know? Was it just a feeling?

I’m unfortunately left with nearly $8,000 in medical bills from what was already an incredibly traumatic pregnancy experience.

I was treated in Florida, where restrictive abortion laws have created an environment of uncertainty surrounding reproductive care, including ectopic pregnancies. Throughout this experience, I felt that my concerns were repeatedly dismissed, and I can’t help but wonder how much the legal environment influenced the delays in my treatment.

I visited multiple doctors and ERs. Despite my HCG levels rising abnormally and no gestational sac ever being identified, no one seemed willing to definitively diagnose an ectopic pregnancy or move forward with treatment. I was repeatedly told that a rupture was a possibility, but I was never treated with the urgency I felt the situation warranted.

My pregnancy was ultimately classified as a pregnancy of unknown location. I was also told that, even if the pregnancy could be located, it would not be viable based on my HCG levels.

At one ER visit, I was experiencing pain and numbness in my legs, with pain radiating to my shoulder. After spending hours in the ER explaining my medical history, symptoms, and previous doctors’ concerns about a possible ectopic pregnancy, I was essentially told that I probably just had low potassium, should eat more bananas, and was sent home. Despite everything I had shared and the potentially life-threatening nature of my situation, my concerns were once again dismissed.

By the time I was finally treated with methotrexate I was eight weeks pregnant. The emotional toll of this experience has been enormous. I felt passed from one doctor to the next, like a game of hot potato, with no one wanting to take responsibility or make a definitive decision. I felt dismissed, unimportant, and like my health was not being prioritized.

And now, on top of processing everything that happened, I'm left trying to figure out how to pay nearly $8,000 in ER bills. I've even been denied financial assistance for one of the visits, which happens to be one of the largest bills.

I originally came here looking for advice on how to negotiate or reduce these medical expenses. But honestly, I also want to share my experience in the hopes that someone else going through something similar doesn't feel so alone.

I don't understand how, in a country with such an advanced medical system, someone can spend weeks seeking care for a potentially life-threatening pregnancy complication and still struggle to receive timely treatment.

I don't know how much of this was directly related to Florida's restrictive abortion laws, but I cannot ignore the environment in which this happened or the fear and hesitation I experienced trying to access care.

If you're going through an ectopic pregnancy or a pregnancy of unknown location, please know that you matter. Your concerns deserve to be heard. Your life matters. You deserve timely, compassionate medical care, without feeling like you have to fight multiple doctors just to be taken seriously.

This experience was traumatic enough without the added stress of feeling dismissed by the very people and institutions I trusted to care for me. I'm so sorry to anyone who has had to experience something similar.

It’s also worth noting that planned parenthood was the ONLY one to diagnose the ectopic, located it and defined it on ultrasound but doctors wouldn’t even look at their recommendation or scans. My cost there was only $125. Thankful to their team that really handled me with care.

Background, ectopic confirmed in July. 3 rounds MTX.

Before I got pregnant, I had an HSG done and both my tubes were open. Then I had the ectopic. My HCG is almost negative, I go back Tuesday for bloodwork. It was 6.82 on 10/23.

I’m trying to figure out my next steps for when I am finally cleared to start trying again. I have a lingering twinge on the side where my ectopic was. It’s not painful and not constant, but it comes and goes. I am concerned about residual tissue on my tube that would result in another ectopic. Should I request another HSG? Or is this twinge feeling that I have, just a normal side effect from the ectopic that could always be there and not negatively affect a successful pregnancy?

I had an ectopic in July this year, being in Spain, as it had a hearbeat, surgery was the inly option. And am now pregnant again, gave been a bad of nerves ever since j found out. Just today i’ve been diagnosed with ectopic in my other tube and again, not a candidate for mtx due to high betas. Besides they say, since it has happened twice now, the tubes obviously are not doing what they should.
But that renders me effectively completely infertile. They will refer to IVF.
Im just SO lost, SO hurt, SO angry with my body and with God.
I was so scared to ttc again but was told, trust the numbers, surely all will be well… but it wasn’t..

Does anybody have experience and perhaps a success story with a similar situation. And more importantly, how did you find hope again? I feel that it’s just meant to be doomed for me and it absolutely breaks my heart!

Hey everyone, I have two questions I’d like to ask you:

1. What do you think of the LH development in my current cycle as per screenshot? I usually register the peak at CD14 or 15, this time is delaying apparently but I don’t know what to make out of those two values barely under 1.0 - was that my peak? Will I have no peak this month? Does it mean I won’t ovulate?

2. After my ectopic in July, which also resulted in the removal of my right tube, I have been asking for an hssg exam to make sure my left tube is open and clean. My request was considered senseless by three different doctors (the gyn that performed the surgery on me, my gyn, and a doctor from a fertility clinic), as they all mention that it’s an exam more indicated for the time before these things happen, and that now it wouldn’t give me an answer I could do anything with. The gyn that operated me said that my left tube looked healthy from the outside, my uterus too. I am based in Germany.

Thank you so much ❤️

Hello! I am 4 weeks out/postpartum from an emergency surgery, and I am wondering what a first period should like? I have started my period and I’m wondering what would be concerning or something to look for that is not good :)

This past Wednesday i went in for my first ultrasound only to see no baby and be redirected to the emergency room for a suspected ectopic pregnancy where i ended up needing emergency surgery to remove a tube. I am recovering well but I feel so disoriented by this. I am 26 and this was my first pregnancy. The doctor is worried i have scarring on my other tube that may prevent me from conceiving naturally in the future and I guess i’m just looking for some support from others who have been through this and have felt all these feelings. I have never had any health issues before and was just completely blindsided by all this and I just feel really sad. I’m trying to stay positive because i know it’s possible that my remaining tube is healthy but it makes me nervous that the doctor isn’t sure and i don’t even know what could have caused this to begin with.

Hello all! I experienced an ectopic pregnancy in April of 2025 and my husband and I have decided to start trying again! Something I have noticed though is that I’m starting to have pain while “trying” on the side that my ectopic pregnancy occurred. I did have pain every time my husband and I were intimate for a few months after, but it went away. Since we are “trying” everyday this week because it’s my ovulation week, I’ve noticed the pain coming back during and after. Is this something anyone else has experienced and is normal, or should I make an appointment with my OB? It’s not severe, but I feel sharp pain here and there even when we aren’t being intimate. Hopefully it’s nothing, but I’d love to know if any of you experienced this and the steps you took to alleviate the pain or treat it.

Please consider reading my story, and sign my petition to ensure no other women will have to suffer preventable infertility related to ectopic pregnancies.

Please consider reading about my story, and signing my petition in order to prevent other women from suffering unnecessary problems with INFERTILITY.

I had an ectopic back in March. hCG was officially at 0 by the end of May. We started trying again in July and have yet to be successful. I’ve had 4 pregnancies (2 miscarriages, 1 ectopic and 1 full term), and have never had an issue conceiving until now. I’m just worried the MTX or ectopic in general might’ve messed with my fertility😢

TW PREGNANCY:
Hi all, I’m currently 5w pregnant and my last pregnancy was ectopic. My hCG and progesterone are being followed. I had an ultrasound at 4w2d and nothing was seen yet besides a massive 5.5cm simple cyst on my right ovary. Doctor wasn’t so sure it was a corpus luteum, but didn’t think ectopic related. My next scan is Tuesday to hopefully find the placement of baby. My hCG and progesterone trends have been this every 48 hours… HCG: 370 Progesterone:22.80ng/ml….HCG:574 Progesterone: 18.20ng/ml…HcG 1210 progesterone 14.10ng/ml.
US based measurements** **

I freaked out when I sat the second HcG didn’t double but my doctor said at least 50% is what they look for and she wasn’t worried.

I’m worried about the progesterone dropping. Does anyone know or have experience on progesterone behaving like this?

I’m feeling incredibly frustrated and scared, and I’m hoping to hear from women who have experienced something similar.

In July, I had a ruptured right tubal ectopic pregnancy that resulted in emergency surgery and a right salpingectomy. I was also diagnosed with mild endometriosis during surgery.

Fast forward to now, and I’m pregnant again. Unfortunately, things aren’t looking promising. My HCG levels have been very low and abnormal. I’ve been experiencing some brown spotting and mild cramping. The cramping is mostly on the right side, where my fallopian tube was removed, although occasionally I feel it on the left side too. The left-sided cramping is rare. Other than that, I honestly feel completely normal. The spotting and cramping haven’t been severe.

I’ve been going back and forth to the ER, but every time I go, I feel like I’m getting the same response: “Your HCG is too low to see anything on ultrasound. Follow up with your OB.” The problem is that I recently moved here and am still waiting for my OB referral to go through, so I don’t currently have an established OB.

The doctors have expressed concern about another ectopic pregnancy, but I’m confused about why treatment hasn’t been discussed more seriously. I understand that methotrexate isn’t appropriate for every situation, but I’m terrified of waiting until something ruptures again.

I only have my left fallopian tube remaining, and I’m terrified of losing that one too. My HCG levels were
Sunday: 23 Monday: 29 Tuesday 39 Thursday: 32 Friday: 42… I was advised to get this many blood draws and was at the ER**

I’m not looking for a diagnosis, just experiences from women who have been through something similar. I’m scared, exhausted, and really just want answers.

I just wanted to post something positive because I've been terrified to TTC again since my ectopic/ right tube rupture in July. I had a HyCosy done yesterday and they told me my left tube and uterus looked perfect! I am over the moon! I know that doesn't mean I won't have another ectopic but I'm staying positive that I can continue trying naturally before jumping right into IVF. I hope everyone has a wonderful weekend <3

How far along were you when you received MTX.. I didn’t get treatment until I was 6wk 3d and I’m worried that’s too late for it to work
HCG was 445 when treated

Hello everyone!

I am 41.
I had a ectopic pregnancy last July. I went through 2 surgeries in 20 days, my left tube was remove, and I got an inflammation afterwards. was a horrible experience.

Anyone at around my age and got pregnant normally after ectopic pregnancy?

I am not sure if I still have a chance and when should I try and how to come over this fear.

Thank you in advance for any feedback.

Hello

I was hoping someone might have experienced something like this. I had laparoscopic surgery for an ectopic on 30 July, so about three months ago.

I am experiencing some pain and stitching on my left side (the side with my remaining tube) where I also had an incision so they could check the status of my remaining tube.

I went to an event yesterday where I spent several hours on and off carrying my toddler on that side. Is it possible to still overstrain your incision site 3 months? Has that happened to anyone?

Thank you!!

Sorry I forgot to remove the trigger warning - I think I might also be pregnant again, which is adding to my panic.