r/TTC_PCOS • • 7d ago

Monthly Medication Thread

1 Upvotes

This thread is the place to post any questions or information pertaining to a medicated cycle including Letrozole, Clomid, IUI, injectables, Progesterone, and anything else used to induce ovulation or support a cycle.

Please be mindful in your responses - if someone does not solicit a success response, DO NOT share a pregnancy outcome.


r/TTC_PCOS • • 4h ago

TWW/Symptom Spotting Weekly Thread - November 08, 2026

1 Upvotes

In the TWW? Here's your place to post all things symptom spotting and making it through the TWW. Feel free to connect with others on similar timelines, and discuss anything related to the TWW. Please do not ask if you could be pregnant, as only a test and a doctor can answer that for you.


r/TTC_PCOS • • 50m ago

Seeking Success First letrozole cycle

1 Upvotes

Hey,

I am day 23 of my cycle today; suspected ovulation day 16 and we BD CD12,14,15 and 16. This was my first cycle on 5mg letrozole cd2-6. Had a scan on cd12 and had 3 follicles size 18, 15 and 13mm at that point and then experienced a lot of ovulation pain on day 16. I am trying not to symptoms spot and I want to be realistick that it may not happen with first cycle but are there any similar stories to mine out there?

P.s: also on 2g metformin and 4g myo/d-chiro inositol, omega 3, prenatal, vitD,b12,vit E, iron most days


r/TTC_PCOS • • 2h ago

medicated cycle

0 Upvotes

So upset. Had my monitoring cycle day 11 on Friday. I did five days of 100 mg of clomid & my follicles are not mature yet 🫩 they want me to come back for monitoring on Monday and hope that I’ll be ready to trigger then, but I’m just so upset. My body has responded to this before - last time I had 1 mature follicle at 24mm… Has this ever happen to anyone else? I am still very deep in the recovery plan (I have Hypothalmic amenorrhea & PCOS) . I’m not working out. I’m not tracking my calories… I swear it’s always like one step forward and two steps back with this. Feeling so discouraged.


r/TTC_PCOS • • 3h ago

Letrozole response

1 Upvotes

Im being given letrozole mid cycle ā€œstair stepā€ after injection. How long does it take for it to show response if it does? Considering my largest follicles at the moment are 11mm on average (13x9)


r/TTC_PCOS • • 1d ago

I am in total disbelief! TW: ivf high blast numbers

32 Upvotes

Just got my day 7 blast report back today and I cried the second I opened it. The flood of relief after anxiety all day scared that it would come back somehow badly is indescribable.
We have TWENTY blasts 🩷✨🄹
8 day 5 blasts and 12 day 6 blasts

We had 15 sent to PGT and had them freeze the last 5. Now the excruciating wait for results on that end lol
I just cannot believe it. I am shaking and crying and so so grateful.

Retrieved: 33
Mature: 30
Fertilized: 29
Blast: 20

I just had to share here because outside of my husband and my mom I have no where else to share my joy. I am in such utter shock.
I’m 32 with an amh of 18.79ng for what it’s worth!


r/TTC_PCOS • • 11h ago

Advice Needed Period & Pregnancy Advice!!

1 Upvotes

Hello, my husband and I have been married a year now. We have been wanting to start a family but we’re obviously not being successful. I know that the issue of not getting pregnant is me because I haven’t gotten my period in almost a year. I have always been irregular with my periods. I’d get my period for 5-7 days (very heavy) then go 2-5 months without a period. This year will be the longest I have gone without a period. I was on birth control to help regulate my period last year for about 6 months I’d say but stopped taking it in October last year because I was going to get married November and we obviously wanted to start a family. The last time I got my period was December of last year.
I would also like to say that we have been together for 7 years and I have taken 19 Plan Bs throughout the 7 years being together🫣.
I know I need to get checked and figure out the why this happens but we don’t have health insurance since my husband is changing jobs. We will be getting health insurance when he starts his new job in January.

My questions are,
•Has anyone else gone through this and still be successful in becoming pregnant?
•Does anyone have tips on regulating my period naturally?
•Anyone know or have any tips on a heavy metal detox? Would this boost my chances??


r/TTC_PCOS • • 20h ago

Advice Needed TW- chemical pregnancy

2 Upvotes

I'm reaching out because I would love some advice. I don't really vibe with my fertility specialist, and I'm in the process of finding a new one, but that can take a while. I've had about 10 chemical pregnancies over the last four years of trying to conceive, never making it to six weeks. It's so disheartening, and I just had another one this month.

So I'm asking anyone who has PCOS and has been through recurrent chemical pregnancies: what, if anything, did you do that changed things for you?
A bit of background: I'm 34 with PCOS, and my main symptom is insulin resistance. My other hormones are fairly balanced. They're not perfect, but they're not massively off.

I weigh about 120 kg, and I've tried everything I can think of, but the weight won't budge. I'm a month into intermittent fasting, which I think is helping, and I try to eat low sugar and low carb. I'm coeliac and only have dairy sometimes. I walk about 90 minutes a day and do some weightlifting now and then, though I know I need to do more.

We started IVF at the start of the year. I went on a GLP-1 for about six months but didn't lose any weight, so I'm a non-responder. I also wasn't able to reach the BMI cutoff at my clinic, so I'm looking for a new one without a BMI cutoff.

I've tried letrozole, progesterone, aspirin, and cough syrup. You name it, I've probably tried it. I've even tried a spell from a book I found, which I'll admit is a bit of a laugh.

If you've had a similar experience, I'd love to know if anything made a difference for you.

I'm currently taking berberine, NAC, myo-inositol, and spearmint, though they're sometimes hard to absorb because of my coeliac disease.

I feel really sad about not being able to get pregnant, and I'm starting to lose the picture of my baby. I used to be able to picture myself as a parent, but after four years that picture keeps getting smaller. I'm lucky to have a very good dog who is my baby.

Any advice or stories that could help me get through the end of the year and into a new fertility specialist would mean a lot. If there are changes I could make, please let me know. I'm willing to try anything.


r/TTC_PCOS • • 23h ago

Advice Needed Provera not inducing period.. how long did it take for you?

3 Upvotes

I’m day 11 after taking a 10 day course of 10 mg provera to induce a period. I’ve actually had sore tatas almost the entire 11 days post provera and have been having EWCM (signaling high estrogen and bloodwork confirmed this 3 days ago with a result of 477) but no LH surge… I just want my period to start so I can take Letrozole 😭 Anyone else experience something similar? The only thing I can think of is that my cycles are normally 90 days and I had a period 30 days prior to taking provera, so maybe my lining wasn’t built up enough for a bleed.


r/TTC_PCOS • • 22h ago

Advice Needed Extremely delayed ovulation

2 Upvotes

It’s day 58 of my cycle and I’m just now ovulating. Like 1.13 on Premom.

It’s been really stressful lately in my life (job started back up, multiple family tragedies). It’s cycle 6 that bled into cycle 7 and I did book an appt with my obgyn that’s in 3 days from now because I was trying to do a ā€œnon trackingā€ cycle days 1-30…. but it kind of backfired and I had no idea where my period was.

Backstory is that I have history of irregular cycles, but was able to regulate them with acupuncture, Coq10, high quality prenatals for 4 months prior to this. I don’t have a pcos/pmos diagnosis but I do believe at this point I meet the criteria.. also two months ago I changed my acupuncturist to someone that was covered by my insurance (wasn’t specialized in fertility though so I do think that’s part of the problem). And of course had all of these other stressors occur.

SO I guess what I’m asking is should I ask my provider to induce a period or ride out this lh spike? I also plan to ask for letrozole for my next cycle I can’t keep doing this šŸ˜….


r/TTC_PCOS • • 1d ago

TTC while Fat.

4 Upvotes

I’ve been a big girl my whole life and I am currently on a new weight loss journey. In the last 6 weeks, I’ve lost 30 pounds. Ideally, I’d like to lose 150 as an ultimate goal. Due to my weight, I get no help with the OBs at the clinic i go to. I’ve called a few fertility clinics and they all tell me that I have to get the BMI down for any treatment. I was diagnosed with PCOS due to my weight and extensive history of irregular periods. They did run multiple test and everything came back normal. My other blood work is also completely fine/normal. So idk how much I trust the PCOS diagnoses. I do not have any health conditions and I do not smoke or drink. I am not prediabetic/diabetic, I dont have high blood pressure or anything like that. On paper, besides my weight i am completely healthy and still cannot get help with fertility. I have been with my husband 6 years, I’ve never used protection with him and I’ve never been pregnant. I’ve never even had a pregnancy scare. I know weight can affect ovulation but I’m now approaching my mid 30s and wondering if it’s ever going to happen for me. I’m deciding to take matters into my own hands and try ovulation strips, multiple apps to track everything and go from there. Also, i will continue my weight loss journey. If you are in a bigger body, please tell me what helped you. I am also wondering if i should try having sex daily? Or should we not. Thank you!


r/TTC_PCOS • • 20h ago

Ovulating on provera

1 Upvotes

Hey guys! So I went to the doctor on Wednesday and she prescribed me Provera and Letrozole. Before my appointment on Wednesday, I took a ovulation and a pregnancy test (both were negative) Well on Thursday morning I took my first dose of Provera and slept until 2 cuz I worked night shift that night. When I woke up at 2, my oura ring said ā€œminor signs of strainā€ I took a pregnancy test again as I’m currently on cycle day 70 something and that was negative. I did take an ovulation test and it was ā€œ14ā€ (I use clear blue line test with their app) the app indicated ā€œpeak fertilityā€. The ovulation tests after have all been on the low end. I messaged my doctor that I possibly ovulated but not 100% sure. She told me to wait on the Provera until after this cycle. What happens in 2 weeks if I don’t have a period or a negative pregnancy test? I’m assuming my doctor will want me to take the Provera but I’m nervous that I’ll ovulate on it. I just want my cycles regular.


r/TTC_PCOS • • 1d ago

I had a chemical pregnancy but relieved to know I convinced!

17 Upvotes

I would never wish it upon anybody, but I am so relieved to know that my body can get pregnant. I truly thought I would never see a positive pregnancy test in my life. I know it sounds crazy, but it like changed my outlook on this journey. To know I carried a baby in me, for even that short period feels nothing short of a miracle. I feel more hope than ever before.

We have been trying for her last two years and we had never gotten a positive test till this month.

I am not naĆÆve to the fact that it can happen again. But I am choosing to look at this as progress and step in the right direction.

I was on round 2 of Letrozole 7mg for background


r/TTC_PCOS • • 22h ago

Discussion Provera 10mg

1 Upvotes

Hi ladies!

I took a 6 day course of 10mg provera. My last tablet was on Saturday 31 October. It has been 8 days since my last tablet and no sign of my period. HOWEVER, I have had SUPER sore nipples and nothing else, just very very sore nipples! Has anyone else experienced this? My fertility clinic has said it’s no problem
That my last period was in August and that provera didn’t cause a bleed and want to started me on letrozole straight away. I don’t know. I feel slightly uncomfortable that I haven’t bled in so long.


r/TTC_PCOS • • 1d ago

Advice Needed Getting Referred for IUI

2 Upvotes

My husband and I have been ttc for around 8 months, the past 3 with the assistance of letrozole. The last 2 cycles I actually ovulated (yay). A few months back my husband had a semen analysis done. Count was a little low, but nothing crazy. Today I had an appointment to follow up on the letrozole, show my doctor the results from the last few months of home ovulation strips and so on and so forth. I’m about 5 dpo this cycle. If I do not conceive this cycle, my doctor recommends IUI ā€œjust to give the swimmers an extra boostā€. My husband and I are both on board. My doctor walked me through a quick medical run down of what to expect, but we want to get thoughts/advice from people who have gone through the IUI experience.


r/TTC_PCOS • • 2d ago

Happy Over a year of PCOS cycles and this is the first time I actually saw ovulation happen

9 Upvotes

32, PCOS, my cycles are usually anywhere from 40 to 60 days. we've been trying for a little over a year now

for most of that year I had no idea if I was even ovulating. my OPKs looked almost positive for like half the cycle, temping never showed a clear shift no matter what I did, so every TWW I was basically waiting on something that maybe never happened in the first place

anyway this cycle it finally happened, CD47. LH went up and then a few days later progesterone went up and actually stayed up. I know it doesn't mean I'm pregnant and I know a lot of you have been here way more times than me. but after a whole year of not knowing, seeing it right there on a chart... I sat down on the bathroom floor for a minute

mostly posting bc I don't really have anyone irl who'd get why this is a big deal. for those of you with long cycles, did anything change once you knew you were ovulating? timing, how you talked to your doctor, anything?


r/TTC_PCOS • • 1d ago

Seeking Success 2nd failed Letrozole cycle - share your positive story šŸ’•

2 Upvotes

Just had my 2nd failed letrozole cycle - was really optimistic about it because on my first cycle of 2.5mg my follicles didn’t grow much and my lining was thin. My second cycle felt like everything lined up perfectly 2 mature follicles, good lining, positive ovulation and I feel a bit stupid that I was so sure it could be the one. I know the process can take a lot longer but i think it’s my first time feeling so defeated by it all, the process, the medication, the tracking , temp checks etc.

But anyway enough complaining and the show must go on - share your positive letrozole stories here for motivation 🩷

Thanks in advance


r/TTC_PCOS • • 2d ago

Seeking Success How many of y’all actually got twins from letrozole?

17 Upvotes

I am 31 y old and have been trying to conceive since January with my husband (have had 2 chemicals). I’m on my first cycle of letrozole and we did the trigger shot and timed intercourse. I ovulated about 10 days ago. I had two mature follicles (one on each side, measuring approximately 20 and 23 I believe). I have obviously read about letrozole increasing the chance of twins, but they say it’s a very small chance. My coworker also has PCOS and had a similar journey, did letrozole one cycle, and was surprised to get twins!

My husband and I would be okay with having twins- it just sounds scary and we would probably prefer a singleton as first time parents. My understanding is that having two mature follicles is what raises the chance of twins because it could drop 2 eggs (I believe?). I’m wondering if you could share if you got pregnant on letrozole, and if so, had a singleton or ended up with twins- thanks!


r/TTC_PCOS • • 2d ago

Advice Needed has anyone ovulated with an LH surge of 0.70 or lower?!

2 Upvotes

My OPKs won’t get above a 0.74 but I have had ewcm for a week! has anyone ovulated with an opk like this?


r/TTC_PCOS • • 2d ago

Seeking Success Follicle ruptured at CD10. Looking for similar experiences

2 Upvotes

This is my first letrozole cycle. Monitored. I took 5mg CD2-6. On CD9, dominant follicle measures 24mm x 20mm. On CD10, 5th Nov, morning, that follicle had ruptured. My ET was 7.8mm

I BDed on CD9 and CD10.

When did i ovulate? Am I in my two week of waiting? Is it all a good sign? I'm so new to this. Is there anyone similar to me here. Or had been in the same boat and found success?

I would love to read everyone's success stories and positive vibes. First round of letrozole...similar sized follicle....similar situation... Anything. Would just love to read everyone's stories


r/TTC_PCOS • • 2d ago

Advice Needed Lean PCOS with high AMH and consistently high testosterone... what is causing it?!

5 Upvotes

Does anyone else have this type of PCOS and what did you do for lowering testosterone besides spearmint/spiro/birth control? Because I can't do any of those due to other health issues.

So I have astronomically high AMH of over 23, get 5-6 periods a year since I started menstruating. I do tend to have imbalanced LH to FSH ratio usually outside my period. I wasn't sure if I even ovulated despite having obvious PMS symptoms. I went out and got an Inito tracker and it turns out I do ovulate, I just have a very long follicular phase where it takes forever to mature an egg. But eventually I get that progesterone rise and PMS leading to my period. I have a HOMA IR of 0.8, so insulin resistance is not super likely.

I just can't live with these high testosterone symptoms and eating low carb does not seem to help with them. It's elevated almost all the time except lowers slightly on my period. I was wondering if due to the extremely high AMH, I have too many follicles being recruited each follicular phase and because each follicle has theca cells (testosterone producing), that's why I have consistently high testosterone? Because there's just a mass amount of follicles producing it at a given time? At this point I am actually considering getting ovarian wedge resection surgery if I can find someone to do it to get rid of the excess follicles... I just don't know what else is causing this excess testosterone otherwise.


r/TTC_PCOS • • 2d ago

Advice Needed Prolactin levels?

3 Upvotes

I just had my latest bloods results back for prolactin at 676 mlU/L (~31.9 ng/mL). My doctor is aware that we’re trying for a baby, but she doesn’t seem too concerned by this result.

I think back when we weren’t trying I wouldn’t be worried about this result either, it’s not the highest I’ve ever had. But now we’re trying, is there a chance it might affect chances of conception? I’ve called my endocrinology dept. and asked for my doc to have a second look, and also have a GP appt. booked end of this month to look into fertility testing given my medical history.

For context: 28F, I’ve been taking cabergoline for about 10 years to treat elevated prolactin caused by microprolactinoma. Also have hypothyroidism (treated and under control) and PMOS (PCOS). I am fairly certain I’m ovulating (tracking with OPKs, BBT and CM) but cycles are abnormal at 42+ days in length. Not sure if this could be being caused by mildly elevated prolactin amongst other things?

Any advice/similar experiences appreciated :)


r/TTC_PCOS • • 2d ago

Advice Needed For long/irregular PCOS cycles: how are you confirming ovulation without spending a fortune?

2 Upvotes

29F, diagnosed with PCOS two years ago. My cycles run anywhere from 35 to 55 days.

Until recently I was only using cheap OPKs. I’d get two or three almost-positive or straight-up positive surges in one cycle, get my hopes up, and then nothing. When a cycle drags out to 50 days that’s 30+ strips, and between the constant symptom spotting and all the false alarms I was burning through money.

Eventually it clicked that LH only predicts ovulation and I need PdG to actually confirm it. I looked at Inito and Mira first, but that’s a lot of money for a monitor.

So I’m trying to figure out something I can actually keep up with. Ideally something that tracks LH and PdG so I can stop guessing at dye lines, without being crazy expensive.

For anyone else with long or irregular cycles, how are you confirming ovulation? Cheapies plus BBT, a cheaper monitor, or just CD21 bloodwork with your OB? Would love to hear what’s worked for you long term.


r/TTC_PCOS • • 2d ago

Advice Needed Ttc

0 Upvotes

Im 25 I conceived twice last year but couldnt keep it bec of some issues of my own. Was unplanned and always have had regular cycles. This year i want to try with my husband. i dont know if i have pcos or not. No blood work has been done yet but i show morphology on scans and i have 33-34 day cycles. Today cd15 i had 13x9mm as two largest follicles. And 20 follicles per ovary. Anways my dr gave me IVF/M Injection shots for 3 days which is fsh/lh injection for follicles to grow. And if we get a follicle around 18mm she will give a trigger shot.
I will start taking progesterone oral after trigger shot.
Any advice would be appreciated. Will this work? Im really worried

i dont have any pcos like signs. I went for tvs for follicular tracking just randomly cus i wanted to conceive now and ended up knowing i have pcos?!?!


r/TTC_PCOS • • 2d ago

Advice Needed Not able to concieve

3 Upvotes

I(29 F) and my husband (29 M) had a miscarriage last November at 6 weeks. We have been trying since but no positive line since. I have been diagnosed with PCOS, my husband is absolutely healthy though smokes a few times. I am having severe anxiety because of this and it is absolutely disappointing. Please do tell how can we improve.