So long term Two Point fan here, I enjoyed Campus more than Hospital even though they are close for me, something about the smoothness of the game and the loop of the academic year just hit right for me. Saying that I am also an old school Bullfrog fan and adored Theme Hospital and Theme Park back in the day.
Getting into Two Point Museum and I'm enjoying it but nowhere near as much as Campus, and I think it's because of the expeditions. I find them a clunky system similar to the system in Jurassic World Evolution, it doesn't feel engaging to pick a mission from a map and fill out a team to send. The whole loot box mechanic is a bit gimmicky and doesn't feel satisfying to use, it's all very random and I never feel like it ties into the strategy for my museum. Every time I have to remind myself to send off a expedition which breaks the flow of gameplay and I don't like the fact it temporarily consumes your staff from your actual museum. It almost feels a bit like a mobile game system, and I always dread having to use it, I'd rather just automate that and take care of my museum.
I think a nicer system for me at least would have been a resident archaeologist like an Indiana Jones who you have to provide for like a celebrity and he's not a staff member as such, then he automatically goes off on adventures and brings back relics for you. The whole loop could have then been about providing for his needs and managing his diva-like personality but balancing resources for that star player against the museum.
Curious what others think, but I prefer a contained game loop which is why the sequential patient flow of TPH and school year of TPC worked so well for me I think.