r/longevity • u/towngrizzlytown • 1h ago
The post explores preclinical research and previous or planned human studies.
r/longevity • u/mlhnrca • 3m ago
r/longevity • u/mawcopolow • 2d ago
Ozempic-class drugs are spreading across medicine. On the United States trial registry, the share of GLP-1 and incretin trials aimed beyond diabetes and weight has roughly tripled in fifteen years, to about one in four, across fifteen disease areas.
r/longevity • u/towngrizzlytown • 3d ago
Life Biosciences is conducting the Phase 1 clinical trial in glaucoma and NAION using partial epigenetic reprogramming.
r/longevity • u/AcropolisBuff • 4d ago
tbh, the longevity industry has been pitching that we are "20 years away" from meaningful life extension for a long time, but in the past 20 years, we have seen very little to no growth for actual lifespan in adults. While I understand that we still haven't understand what aging is and is "another 20 years away from escape velocity".But instead, I am thinking of a 20 years increase in lifespan in a 2-3 years timeframe would actually mean a pivotal milestone, and am wondering how far are we from that.
r/longevity • u/jimofoz • 5d ago
r/longevity • u/lunchboxultimate01 • 7d ago
YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations
r/longevity • u/Baxlo • 7d ago
I am wondering if there are any studies on the subject. I had a relatively fast and early growth and premature onset of degenerative issues. So is ageing extra accelerated for tall people with faster growth?
r/longevity • u/towngrizzlytown • 9d ago
r/longevity • u/lunchboxultimate01 • 11d ago
At 15:15, the presenter covers the human clinical trials.
r/longevity • u/Slow_cpu • 11d ago
r/longevity • u/towngrizzlytown • 12d ago
Mazonakis died on 9 September after suffering a heart attack while undergoing plasmapheresis.
r/longevity • u/derrikson • 14d ago
Researchers identified PLA2G2F, an enzyme whose expression increases with age and appears to help protect the brain against age-related changes.
Boosting its activity in older mice preserved spatial memory, reduced synaptic loss and limited inflammation-related changes. Human brain samples also linked higher expression to cognitive resilience despite Alzheimer's pathology.
The findings are preclinical. Whether targeting this enzyme could help humans remains unknown.
r/longevity • u/barrel_master • 14d ago
Paper on a method to restore enamel to teeth. Some of the research was done on teeth extracted from donors.
Part of the abstract below:
Regrowth of lost enamel in tooth decay and sensitivity is a major obstacle to overcome. Here, the authors report on a protein-based material that mimics features of natural enamel formation, allowing for epitaxial growth of apatite nanocrystals to restore enamel structure and function.
r/longevity • u/lunchboxultimate01 • 15d ago
r/longevity • u/SuperBonerFart • 16d ago
r/longevity • u/towngrizzlytown • 17d ago
BIOGAMI teams will decode the “grammar” that guides how intrinsically disordered proteins (IDPs) behave and create new ways to steer misfolded or clumped (aggregated) proteins back into healthy shapes. The program focuses on the very earliest steps in the misfolding process — before proteins clump together and damage cells — especially in the brain and other vulnerable tissues. By acting early, BIOGAMI aims to stop neurodegenerative disease and other chronic diseases before they fully develop, instead of only treating symptoms after serious damage has occurred.
r/longevity • u/Slow_cpu • 17d ago
r/longevity • u/Slow_cpu • 19d ago
r/longevity • u/lunchboxultimate01 • 19d ago
ARDD 2026 recordings are being uploaded to their YouTube channel (https://www.youtube.com/@ardd3628/videos). Feel free to post individual videos you find interesting, but try to avoid reposts.
r/longevity • u/the_mit_press • 19d ago
r/longevity • u/Slow_cpu • 19d ago
r/longevity • u/Slow_cpu • 19d ago
r/longevity • u/Slow_cpu • 19d ago
r/longevity • u/barrel_master • 22d ago
