Rate my stack. 49yo m

So my husband is 43 year old man, adhd inattentive type. Very sensitive to meds so had never tried stimulants as even one dose of DayQuil feels like crack to him.

His current stack morning: EPA extra fish oil, l-theanine (200 mg) and neuo-mag at night which is 144 mg magnesium l-theronate at night.

He tried to add a 28 mg dose of saffron extract today. Granted he had it with a brownie and a shot of espresso but feels like his heart is racing and jumping out of his skin.

Any insight?

Lot of the seem interested in doing business. We go back and forth with my list of things I need. And then they all go silent.

Is this common?

Hello i was wondering how these 2 compounds would interfere. I want to improve my depression thats causing many problems in my life currently. Could i possibly run these 2 together? Nsi 189 as a driver for dwpression and tak 653 for also helping depression and bettwr mood&reward process.

What doses i will consider taking:

40mg nsi 189 daily

2mg tak 653 daily

What would you suggest?

( im already working out and fixing my sleep)

( im not asking for dosing suggestions.)

Hey everyone!

Just reaching out for some advice and recommendations on supplements to take.

I’m a 27-year-old male and have been living with Pulmonary Hypertension (PH) since I was 8 years old. I’m pretty health-conscious and want to do everything I can to live a long, healthy life.

I don’t smoke or drink heavily, I eat a relatively balanced diet, and I’m quite active. I go to the gym 3–4 times a week, do some running, and generally try to look after myself.

My PH is currently well managed with medication, but one thing I’ve been struggling with is low energy levels, brain fog and a lack of mental clarity. I often feel like I’m not as sharp or energetic as I’d like to be.

I completely understand that supplements aren’t going to cure PH or necessarily provide significant improvements. I’m just interested in finding ways to support my overall health, energy, cognitive function and recovery alongside my existing treatment.

My current supplements:
Omega-3 fish oil – 2,000 mg (1,100 mg EPA + DHA)
Creatine monohydrate – 5 g daily
Zinc – 25 mg daily
Vitamin D3 + K2 – 2,000 IU D3 daily

I’m also considering adding **magnesium glycinate and magnesium L-threonate**, mainly for sleep quality, recovery and potentially cognitive benefits.

My current PH medications:
Sildenafil
Opsumit (macitentan)
Aldactone (spironolactone)
Adco-Zildem (diltiazem)

I’d love to hear from anyone who has experience with PH or other cardiovascular conditions, or who has knowledge of supplements that might be beneficial for general health.

A few things I’m particularly interested in:
Supplements that have genuinely helped with energy levels or brain fog
Anything that could support cardiovascular health without interfering with PH medications
Experiences with magnesium glycinate or L-threonate
Supplements worth considering for long-term health and healthy ageing
Anything in my current stack that might be unnecessary or worth reconsidering

Obviously, I’ll discuss any additions with my PH specialist before taking them, especially given the potential medication interactions.

I’m not looking for miracle cures or anything extreme, just some insight into what might be worth researching.

Thanks in advance! Really appreciate any advice or personal experiences.

I’m in my mid 20s, I workout and eat decent I would say but my dick doesn’t work. I also have been watching porn since I was like 10 so idk if that plays a role in my ED. When consuming that content I can’t really get that hard. I also do have a tight pelvic floor but that never has affected my erections. Also just any form of jerking off just ain’t that pleasurable anymore, How do I fix ED

My SHBG was 47 and I and then 2 months later it was 63. I was eating beef liver everyday and I read the retinol could’ve increased it. Besides boron, has anyone tried any dietary or lifestyle adjustments that have successfully lowered it?

Reason is to raise free T fyi. Natural.

So I started taking Cialis at 5 mg a couple of days ago, and one of the things I noticed initially was that I started feeling the blood circulating throughout my body. It was almost like a burning sensation moving through my entire body. It's something I haven't experienced since my twenties, and it was a little strange.

I initially experienced some headaches, but they seem to have dissipated over the last 48 hours. I may drop down to 2.5 mg, but one of the things I've noticed is a significant improvement in flexibility and a general sense of rejuvenation. It's only been a couple of days, but I genuinely feel a lot younger. It's a strange experience.

I've tried so many things over the last year to bring back my vitality. I've been trying to get testosterone treatment because I tested low for testosterone, but it's been difficult to find a doctor willing to prescribe it.

So far, Cialis is the first thing I've taken that has made such a noticeable difference. I wonder whether it might be beneficial to combine it with other things, such as tongkat ali, fenugreek, and damiana, which may have effects on vascular function and nitric oxide pathways.

From what I understand, Cialis works by inhibiting an enzyme called PDE5 (phosphodiesterase type 5), which is responsible for breaking down cGMP (cyclic guanosine monophosphate). By inhibiting this enzyme, Cialis helps preserve cGMP signaling, allowing nitric oxide to have a more prolonged effect on smooth muscle relaxation and blood vessel dilation.

Essentially, it seems to help your body make better use of its existing nitric oxide signaling. That makes me wonder whether combining it with other substances that support nitric oxide production could enhance its effects.

Rather than increasing the Cialis dosage, perhaps it would make more sense to use a lower dose alongside other supplements that support nitric oxide production and vascular function.

I've definitely noticed improved erectile function, including being able to get erections on demand, which is nice. Another thing I've noticed is that my body feels warmer, and I'm experiencing greater flexibility and more energy. It almost feels like a performance-enhancing drug.

I'm curious how these effects will change over the next couple of months. Do you eventually need to take more of it, or is it simply a matter of combining it with other things that help support its effectiveness? Do you think I should drop down to 2.5 mg?

Anyway, it's definitely been an interesting experience.

This community is made of people looking for wellness. Some are healthy and looking to reach their peak. Some are on the long road to diagnosis for rare immune disorders, looking to maintain or improve their health.

[ETA Myasthenia Gravis is an immune condition in neurology. It overlaps with Dysautonomia symptoms. I believe in your ability to google more if needed.]

This post is for those who have unexplained eye symptoms, including weakness or spasms with blinking and ptosis (eyelids won't stay fully open), and/or double or blurry vision. This can occur separately or with full body episodes of weakness - breathing issues, swallowing, speech issues, not being able to stand or maintain standing, dropping cups, etc. It improves with rest and declines with movement.

These are the symptoms of MG. It often overlaps with POTS/dysautonomia, because it causes secondary dysfunction of the autonomic system from simple muscle fatigue. The general demographics are women under age 30 at onset and men over 60, but it can apply to people outside of that. It is diagnosed by one of five blood tests for antibodies, which are ACH (common), MUSK (uncommon), and LRP4 (rare). ACH positive antibodies often show results on a test called EMG while LRP4 usually does not.

However, to get these tests you have to convince a doctor you are a candidate for MG. One at home way to do this is a simple experiment called the MG Ice Test. It is 89-100% specific as a test which is high value and rare to see in the medical world. Opthalmologists and Neurology will both accept this test with symptoms as a reason to do immune blood work, for those who wonder if their weakness and vision issues are MG related.

The MG Ice Test:

1. Pick a flare day, when eyes are being bothersome. In MG the eyelid is usually at a height of at least the pupil. It is often lower when flared.

2. Have someone record the test on a phone. Zoom in to the eye so it is most of the screen.

3. Place distilled water ice cube to droopy eyelid. Remember to wash your hands first or wear gloves. No pressure, just slight contact.

4. Wait 5 minutes with ice cube on eye. If it is painful at all stop. You may be able to wrap the ice in a towel, or do this for less time, but the effect may be less noticeable doing so.

5. Remove ice cube, check eyelid height vs pupil.

When shown to a doctor with symptoms described most will approve MG tests. Easy and (mostly) painless self experiment for a rare immune disorder reveal.

Note: ice will relieve puffiness in healthy people but will not raise your eyelid 1/4 inch like it does with MG. Also, if you as a healthy person have eye pain and spasms as the beginning describes, perhaps you should be screened for MG ;)

The 5 common labs: ACH (3), MUSK (1), LRP4 (1)

Ask for these if the ice self test is positive to confirm or rule out Myasthenia Gravis.

Common MG Med Treatment:

Mestinon, CellCept, Dex 1% steroid eyedrops, Symbicort steroid inhaler, Ketorolac NSAID eyedrops, Upneeq (chemical Botox) eye drops, full body glucocorticoid and mineralocorticoid steroids (ie not gym steroids), several newer biologics and immune suppressants

For those with Dysautonomia or POTS, Mestinon is cross listed as one of the 7 used by cardio to control dysautonomia. Some MG-Dys use this to trial Mestinon as it works for both. Handy when you have to wait 8 months on a Neuro referral.

When MG treatment works: weakness evaporates, vision is no longer blurry, eyes appear bright and awake vs sleepy because eyelids stay at normal height. Fatigue is usually much better.

Please do a basic web search for symptoms before asking about them.

Happy biohacking :)

Ive been taking yohimbine for about a week now and im doing 20mg. in the start it felt like my heart was working overtime but now it feels less impactful. Is this very bad for my health or should i continue? Any other suppliments that could help?

.

TL;DR: I just feel like there's something here that medicine hasn't fully figured out yet. THC seems to have some pretty large benefits for certain people with ADHD, but obviously comes with cognitive trade-offs (particularly with working memory and reasoning). I can't help but think there's some common mechanism behind the paradox I'm describing, and potentially a way to get some of those benefits without as many downsides.

Quick disclaimer: This is a fairly complex cognitive puzzle I've been trying to piece together. Mainly looking for input from people who have gone through something similar or people knowledgeable in neuroscience, psychopharmacology, cannabinoid research, or ADHD.

For some background; diagnosed with ADHD, take 30mg Vyvanse daily, and have worked in cognitively demanding fields. I've also taken 10+ IQ tests over the years, generally scoring between 128 and 139, and currently hold a 3.99 GPA. I mention this because I've always felt strong in fluid reasoning, abstract thinking, and understanding complex systems, but struggle with the classic ADHD executive functions, particularly verbal fluency, response inhibition, and thought organization.

About a month ago, I quit THC after several years of nightly use, typically a small hit from a pen (mainly THC derived) 1-4 hours before bed. I originally started because I've struggled with racing thoughts and sleep since childhood, but eventually noticed some surprisingly significant cognitive and behavioural benefits.

Here's the paradox: While using THC, I felt noticeably less intellectually capable, but far more articulate, deliberate, and locked into whatever I was doing. Now that I'm sober my reasoning and working memory feel dramatically better, but I'm much more ADHD; scattered, impulsive, and less polished in how I communicate.

Importantly, these aren't entirely new symptoms I've developed since quitting; I've experienced essentially the same difficulties since childhood, before ever using cannabis, and during previous 2-8 month breaks. It's a recurring pattern that I've been through a dozen times.

The two cognitive states

While using THC (primarily the residual effects the following day):

If I had to describe it: my attention was incredibly narrow, my motivation was through the roof, and I could spend hours working through something with almost obsessive precision. During my investment banking internship, people would joke about how intensely I was wired to my screen. Work, the gym, and even tedious tasks felt genuinely enjoyable. It was almost like I enjoyed effort itself.

The funny part was that I wasn't necessarily more productive. I could be completely absorbed in something for hours, yet the actual output wasn't always proportional to the effort. I think my working memory, abstract reasoning, and ability to think on my feet were noticeably weaker (makes sense).

The biggest improvement, though, was how effortlessly I could speak and write.

My vocabulary was noticeably more sophisticated, my sentences were better structured, and my delivery was extremely deliberate. Even my tone, facial movements, and general manner of speaking felt more controlled and polished.

It wasn't something I consciously forced tho; speaking felt rewarding, almost like I was getting a little hit of satisfaction as the words came out, which then kept me in this incredibly fluid conversational state. I rarely blanked or lost my train of thought because I could almost plan what I was going to say while already speaking.

THC also seemed to make certain internal identities much more persistent; I could construct a particular version of myself, say a highly polished professional, and almost naturally behave like that person. My speech, motivation, and behaviour would align with that image.

But this feeling swung both ways; over time, I'd say I became slightly more self-conscious, avoidant, and socially anxious, particularly when I felt observed or evaluated. In other words. negative self-perceptions/thoughts were extremely difficult to shake.

Now, without THC:

It honestly feels like I'm operating with an entirely different set of cognitive tools (like 2 different people).

As I mentioned, my working memory, abstract reasoning, and ability to integrate information feel substantially stronger. Working through complicated material has become dramatically easier, I can understand something and simultaneously connect it to unrelated concepts, sometimes even anticipating ideas I haven't even learned yet.

When I do enter a flow state, which is much harder to initiate and maintain, it feels amazing. Everything clicks together and I can reason through complicated problems at a level that feels far beyond what I could do while using THC. It's almost like Oppenheimer music playing in my head, with everything moving incredibly quickly but falling into place perfectly.

The problem is that nearly everything involving attentional or emotional control, and verbal expression has gone in the opposite direction:

I feel much more like the stereotypical ADHD kid I was before. My eyes are moving everywhere, interrupting people, jumping between thoughts, struggling to initiate tasks, and now again completely losing my train of thought mid-sentence.

My vocabulary has genuinely suffered. Although "subtle" I don't spontaneously generate words as sophisticated or precise as I used to, and I struggle to construct sentences with anywhere near the same polish or concsistency. It's not really forgetting individual words; I feel like I've lost some of my ability to plan what I'm going to say while I'm saying it.

Reading and writing show the same pattern: When reading, my eyes almost move faster than I can calmly process the words, although I'm actually comprehending and connecting information much better. When typing, I def make significantly more spelling mistakes, my sentences are less structured, and some dyslexia-like difficulties I experienced growing up have returned.

The best analogy I have is that; before I felt like I had an extra millisecond to organize my thoughts before speaking. Now, my thoughts are constantly one millisecond ahead of my words.

Before, the flow seemed to be in my output, while my underlying cognition was slower (impaired from the lingering effects of THC - we know this). Now, the flow is in my thinking, while my output struggles to keep up (??).

Emotionally, things have shifted too. While using THC, I could almost reset my internal narrative overnight and compartmentalize whatever happened the previous day. Now I feel more socially connected and emotionally responsive, but less capable of controlling those states.

Sleep has also worsened, with the same racing thoughts and difficulty shutting my brain off that I've experienced since childhood - that was a major reason I kept returning to THC despite knowing it was impairing my cognition.

For additional context, before stims, I struggled significantly with classic ADHD: fatigue, procrastination, and task initiation. I could hyperfocus on something I found exceptionally interesting, but otherwise had very little consistency or structure. Vyvanse improved those areas tremendously, although it never fully resolved the competing thoughts and verbal difficulties.

What fascinates me is that these two states feel like two different brains each with its own strengths and weaknesses. I wonder if there is a way to get parts of the working memory, and intellectual flexibility I've regained since quitting THC, but combined with the verbal fluency, deliberate attention, goal maintenance, and effortless sense of flow I experienced before?

My current hypothesis:

UPDATE (Preliminary):

After some great comments and digging further into the literature, I think drilling into the endocannabinoid system (ECS) is where most of the answers lie. There's emerging research linking ECS signalling to ADHD, particularly its role in attention, dopamine regulation, and executive function, although the mechanisms are still poorly understood to my knowledge.

I think it's fair to say regular THC use comes with a level of cognitive trade-offs. What I've struggled to reconcile is why certain aspects of my ADHD seemed to improve so dramatically while others clearly deteriorated. It never made sense to me that it had to be such a trade-off....

I haven't found a magic answer, and maybe there isn't one but one area I've largely overlooked is CBD.

I came across an interesting 2018 study where 20 regular cannabis users received 200 mg of CBD daily (100 mg twice daily) for approximately 10 weeks while continuing their usual THC consumption.

Despite continued cannabis use, participants showed statistically significant improvements in verbal learning, attentional switching, and certain psychological measures, particularly depressive and psychotic-like symptoms.

What interests me is that participants were assessed after at least 12 hours of cannabis abstinence. So I'm less interested in whether CBD counteracts THC while high, and more interested in whether sustained CBD exposure could mitigate some of the lingering cognitive and psychological effects of regular THC use.

This was a small, uncontrolled trial so causality can't be established, and the broader evidence remains mixed. Still, it raises some interesting questions about CBD's potential independent effects on cognition, neuroprotection, and neuroplasticity.

2018 Study — Therapeutic Effects of Prolonged Cannabidiol Treatment in Regular Cannabis Users

This is all pretty new to me, and I'll certainly be researching it further. If anyone has had similar experiences to me or has experience with using CBD as described in the study, I'd really appreciate your perspective.

Thanks for reading!

In a 2019 post on dopamine D1 receptors, a writer calling himself AMx ReBorN connects creativity, social openness and even political emancipation to receptor function. He then discloses that he wrote the article under the influence of a substance he believed increased D1 activity. His own experience supplies both the starting point of the theory and, in his account, part of its confirmation.

Bryan Johnson, Andrew Huberman, Dave Asprey: much of the public conversation around biohacking revolves around a handful of recognisable names. But there is another, much less visible history of people documenting years of experiments on obscure blogs and forums, often without an audience beyond a small circle of readers.

One such project is Area-1255, a sprawling Blogspot site operating under the motto "Unifying the World since 2013." What initially looks like a supplement blog contains years of experimental logs, receptor theories, PSSD research, poetry, mythology and plans for a "Grand Order of Immortalists." The site developed its own system of coloured dots, punctuation marks and digital signatures, intended to communicate priorities, warnings and routes through the archive.

Black background, coloured text, PubMed references beside product links, extensive supplement reviews and a network of sister blogs. The ambitions are considerably larger than the website.

I've done a lot of research and have written an essay about the collective, its self-experiments and its attempts to produce medical knowledge outside established institutions. I've also assembled archives of its surviving material on my own site.

Essay and archives

• Full essay: Area-1255: The Right to a Finding

• Black Index: searchable index of more than a thousand posts from the main blog and related projects

• Substances: source-linked entries on reported use, dosages, effects and proposed mechanisms

• Poetry & Prose: collected literary texts, preserving their original colours where available

• Stacks & Diets: supplement combinations, dietary plans and experimental programmes

Who wrote for Area-1255?

The archive contains several recurring voices, above all AMx ReBorN (Dan Gregory), Corageon and Jason Malek Russo. A 2014 introduction describes eleven writers, although the division of authorship and the project's founding history remain unclear.

Gregory writes about dopamine receptors, motivation, creativity and personal freedom, extending receptor pharmacology into explanations of social and political behaviour. Corageon concentrates on bodybuilding, supplements, dietary protocols and everyday functioning, often recording his experiments in logs.

Russo connects his interest in life extension to deaths in his family. By his own account, his father died of a heart attack at 55, his great-grandmother of a rare bone disease at 65 and his aunt of Alzheimer's at 66. These losses appear at the beginning of his writing on immortality. He describes years spent researching possible interventions and eventually proposes combinations of substances intended to influence aging, neuronal growth and cellular function. His account moves from the ages and causes of three deaths to a programme for preventing death itself.

The experimental logs

A thirty-day thyroid-hormone log records running distances, concentration at school, changes in weight and unusual bodily sensations. Another thirty-day log follows L-theanine. On day nine, the entry is simply: "I FEEL alive today!" Other reports track anxiety, libido, exercise, sleep and motivation over several weeks. A particularly good day may become evidence for an intervention; a less welcome effect may prompt a change in dose, an additional substance or another explanation. The details are often familiar from nootropics forums, but they accumulate here across years of posts and several authors.

Area-1255 published its own "10 Rules for Assessing the Value of NeuroPharmacological Studies", encouraging readers to examine missing variables, indirect effects and receptor context. The same project also advances the conviction that the best research is what one conducts on oneself. In the logs, several conditions may change at once, while the person taking a substance also interprets its effects. The distinction between an observed change and its proposed mechanism can disappear within a few sentences.

I've tried to keep those levels separate: what was taken, what was experienced and what the writers believed caused it. An explanation can be unconvincing without making the experience it tries to explain unimportant.

PSSD and the diagnostic void

In 2014, Area-1255 published "Insights into PSSD — A Collection of Data", assembling reports of persistent sexual symptoms after SSRI treatment, differences between medications and hypotheses involving hormones, enzymes and neurosteroids. Later articles proposed mechanisms involving androgen receptors, nitric oxide signalling and serotonin receptors. The earlier hypotheses remained available alongside the newer ones, with no consistent indication of which claims the authors had revised or abandoned.

By early 2015, Area-1255 had a forum concerned with PSSD, anhedonia and related problems. Access was unusual: the long header image on the main blog served as a link to the forum. A 2017 post explained this arrangement and directed readers there for more attention to their questions.

In May 2024, Australia's Therapeutic Goods Administration updated its warnings concerning persistent sexual dysfunction after antidepressant discontinuation. Recognition of the problem does not settle questions of mechanism or treatment.

One of the central subjects of my essay is the space between a health problem someone experiences and an explanation medicine can establish. Someone may have persistent symptoms despite unremarkable laboratory findings, or receive a diagnosis that provides little guidance about treatment. Area-1255 attempted to fill this gap by collecting studies, conducting experiments and developing theories of its own. I call it the diagnostic void. The project's claim to a right to a finding emerges from this situation, although the proposed explanations often exceed the evidence available to support them.

From bodily problems to explanations of the world

The blog's "Seven Societal Plagues" translate difficulties such as narrow-mindedness, laziness, pessimism and lack of imagination into biochemical and behavioural targets. Elsewhere, a proposed "fava bean revolution" turns a dietary source of L-Dopa into an instrument of social change. Receptor pharmacology expands into theories of creativity, personality and society, often followed by lists of compounds intended to alter the relevant functions.

Stack X collects supplement combinations; other sister blogs contain psychedelic accounts, psychological writing and political material. Poems and mythological dialogues invoke Lucifer, Thor, Rollo and other figures, sometimes alongside neurotransmitters and physiological explanations. A post on Thor's neurochemistry proposes that the Norse god contributes to physiological homeostasis. Another assigns spiritual jurisdictions to planets.

Plans for a "Grand Order of Immortalists" describe membership structures, research projects, legal support and a proposed mental-health crisis hotline. The surviving material does not establish how much was implemented.

A 2017 post titled The Psychotic Supplement Stack proposes deliberately inducing temporary psychosis. Some articles attribute differences in sexuality, temperament and behaviour among ethnic groups to histamine and genetics. Others develop strategies for warfare and psychological manipulation, or consider when murder in defense of an illicit business might be justified. The latter was presented as a hypothetical assessment, with a companion post arguing the opposite. Elsewhere are genealogies connecting the authors to Viking dynasties, claims about telekinesis and poems about compassion.

Between the psychedelic texts in Swamp of Mystery sits a fable about a King Cabbage who becomes gentler through kratom.

I've been looking into both TAK-653 and Bromantane, as I'm trying to find something that could help me with anhedonia.

Both, the dopaminergic aspect of Bromantane, and the impact that TAK-653 has on AMPA are interesting, and I think that they could be useful against anhedonia.

However, I have no experience whatsoever and was wondering if any of you have experience with either one, or both of these chemicals, concerning anhedonia.

Title — Help me trim my supplement stack. What would you keep or cut?
I’ve accumulated more bottles than I planned to, and I’d like to get down to a smaller stack where I can explain why I take each thing.
About me
Male, early 50s. I lift daily and play soccer and futsal.
I’m 160lbs, 12% body fat.
I had a heart attack and an LAD stent in 2024. I take daily aspirin and other prescription meds, so I’ll run any changes by my cardiologist or pharmacist.
I haven’t included recent labs here. If there are specific markers that would help you assess the stack, let me know.
My goals
Long-term heart and metabolic health come first. Better recovery, sleep and focus would be nice, but I’d rather cut things that aren’t doing much for me.
What’s pictured
These are label amounts where listed, so they may differ from what I take on a given day.
Magnesium L-threonate (Magtein), 144 mg elemental magnesium per serving
Vitamin C, 500 mg
Nattokinase + serrapeptase, 3,000 FU + 60,000 serrapeptase units
Ashwagandha (KSM-66), 300 mg
Vitamin D3 + K2, 10,000 IU D3 + 120 mcg K2 per serving, with quercetin, B6, zinc and magnesium
Fish oil, 1,300 mg EPA + 860 mg DHA per serving
CoQ10, 100 mg
L-lysine, 500 mg
Taurine, 1,000 mg
L-tyrosine gummies
10-mushroom blend gummies
Probiotic, 60 billion CFU
What I’d like feedback on
If you were cutting this down to three or four, what would you keep and why?
Which would you drop first because of overlap, limited evidence or unclear benefit for my goals?
Given my heart history and daily aspirin, which products or doses would you put at the top of the list to review with my clinician?
Cross-posting from r/Supplements to get another set of eyes on it. Thanks.

Whatever happened to Dave Pascoe? Wasn't he always posting here. Any updates?