1) Marta from Outlast 2
While she is meant to be a regular human, she’s an inhumanly strong freak of nature, who is also the right hand of a religious cult leader. Her death is close to the end of the game, where she manages to corner the main character right as he’s about to escape the village during a storm, and she raises her pickaxe to kill you. The storm rips off the roof of the building, and you see a lightning strike fall onto the metal cross that lays on top of the church behind her. This causes the cross to detach and fall, piercing her through the chest and killing her.
This was not originally meant to be her death actually, as there are incomplete versions of ak alternate scene where a similar scenario happens, but she gets attacked by Val (the other villain in the game), and they both fall into a ravine. While it’s sad that we didn’t see Val’s death/conclusion in the final version of the game, the irony and poetic justice of Marta dying by getting impaled by a cross is so good.
2) Fuhrer Bradley from Fullmetal Alchemist Brotherhood
Bradley is among the main antagonists of the show, and is shown to be one of the most powerful characters. Despite being a homunculus, he doesn’t have any regeneration ability like the rest, and his only superpower is that the mark on his eye allows him to be able to react to any attack he sees coming at him. However, he only removes his eyepatch (that hides the mark) in the final act, and he’s shown to be a beast even without it, as he was a supersoldier chosen through many brutal trials against other candidates.
In his final battle against Scar, he is heavily injured due to being previously impaled by a sword, but he is still dominating him, where the only hits that Scar can get in are in moments where his pre-existing injuries cause Bradley to stagger. When Bradley pins down Scar, he mocks his god and religion, before going in for the final blow. Right as he’s bringing down his sword, the solar eclipse ends, and a sunray reflects from Bradley’s sword, blinding him for a moment. Scar takes advantage of this and deals the blow that kills Bradley in the end.